Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington’s disease via suppressing MAPKs and NF-κB pathways in the striatum
| Autor: | Zhen-Zhen Wang, Fang-fang Li, Yu-He Yuan, Nai-Hong Chen, Xiong Yang, Shifeng Chu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Ginsenosides Apoptosis Striatum Pharmacology Neuroprotection Article Mice 03 medical and health sciences chemistry.chemical_compound Ginseng 0302 clinical medicine Huntington's disease medicine Animals Pharmacology (medical) Mitogen-Activated Protein Kinase Kinases Neurons Microglia Chemistry NF-kappa B NF-κB General Medicine Nitro Compounds medicine.disease Corpus Striatum Mice Inbred C57BL Huntington Disease Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Propionates Signal transduction Signal Transduction |
| Zdroj: | Acta Pharmacol Sin |
| ISSN: | 1745-7254 1671-4083 |
| DOI: | 10.1038/s41401-020-00558-4 |
| Popis: | Huntington’s disease (HD) is one of main neurodegenerative diseases, characterized by striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, possesses a variety of neuroprotective effects with low toxicity and side effects. In this study, we investigated the potential therapeutic effects of Rg1 in a mouse model of HD and explored the underlying mechanisms. HD was induced in mice by injection of 3-nitropropionic acid (3-NP, i.p.) for 4 days. From the first day of 3-NP injection, the mice were administered Rg1 (10, 20, 40 mg·kg −1 , p.o .) for 5 days. We showed that oral pretreatment with Rg1 alleviated 3-NP-induced body weight loss and behavioral defects. Furthermore, pretreatment with Rg1 ameliorated 3-NP- induced neuronal loss and ultrastructural morphological damage in the striatum. Moreover, pretreatment with Rg1 reduced 3-NP- induced apoptosis and inhibited the activation of microglia, inflammatory mediators in the striatum. We revealed that Rg1 exerted neuroprotective effects by suppressing 3-NP-induced activation of the MAPKs and NF-κΒ signaling pathways in the striatum. Thus, our results suggest that Rg1 exerts therapeutic effects on 3-NP-induced HD mouse model via suppressing MAPKs and NF-κΒ signaling pathways. Rg1 may be served as a novel therapeutic option for HD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink