The genomic organization of the human GLP-1 receptor gene
| Autor: | Füller P, Andreas Wilmen, Walkenbach A, B. Göke, Brigitte Lankat-Buttgereit, Rüdiger Göke |
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| Rok vydání: | 2009 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Secretin receptor family Biology Exon shuffling Glucagon-Like Peptide-1 Receptor Exon Endocrinology Receptors Glucagon Internal Medicine Humans Coding region RNA Messenger 3' Untranslated Regions Gene Genomic organization Genetics Genome Splice site mutation Intron DNA Exons General Medicine Molecular biology Introns 5' Untranslated Regions hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 106:299-302 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1211989 |
| Popis: | The genomic organization of the human gene encoding the receptor for glucagon-like peptide-1 (GLP-1 (7-37)/(7-36) amide) was analyzed to reveal the relationship to other G-protein-coupled receptors. The coding sequence of the GLP-1 receptor is interrupted by 12 introns. These introns are uniformly distributed within the open reading frame. The length of the introns varies between 6.6 kb and 100 bp, in contrast to the relative constant length of 100 bp of the exons. All of the exon/intron splice junctions characterized followed the consensus GT-AG rule. A comparison of the genomic structure with other related receptor genes indicates that the exon/intron organization is well-conserved among the VIP/ glucagon/secretin receptor family. |
| Databáze: | OpenAIRE |
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