Chlorhexidine-alcohol versus povidone-iodine as preoperative skin preparation to prevent surgical site infection: a meta-analysis
| Autor: | Tasya Anggrahita, Aditya Wardhana, Gentur Sudjatmiko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
lcsh:R5-920
medicine.medical_specialty Adult patients business.industry povidone-iodine Chlorhexidine General Medicine Publication bias skin antisepsis surgical site infection 030230 surgery Jadad scale Surgery 03 medical and health sciences chlorhexidine-alcohol 0302 clinical medicine Relative risk Meta-analysis Medicine 030212 general & internal medicine lcsh:Medicine (General) business Surgical site infection Skin preparation medicine.drug |
| Zdroj: | Medical Journal of Indonesia, Vol 26, Iss 1 (2017) |
| ISSN: | 2252-8083 0853-1773 |
| DOI: | 10.13181/mji.v26i1.1388 |
| Popis: | Background: Surgical site infection remains substantial problems to surgeons and patients as it increases the morbidity, mortality, length of stay, hospital cost, rate of re-admission, and rate of re-surgery. This study aims to compare the use of chlorhexidine-alcohol versus povidone-iodine for preoperative skin preparation to prevent surgical site infection.Methods: The literature search was conducted through the PubMed database on November 2015. Included studies were RCTs with the year of publication up to 2015 which compared the use of chlorhexidine-alcohol versus povidone-iodine in its effectiveness reducing surgical site infection in adult patients. The quality of the study was assessed using Jadad Score. A meta-analysis was conducted in the included study to obtain a pooled estimate of the effect size. The evidence of heterogeneity and publication bias was also assessed.Results: Six RCTs with a total of 2,080 patients were included in the meta-analysis. It showed that the use of chlorhexidine-alcohol was associated significantly with fewer SSIs (pooled risk ratio=0.60 (95% CI=0.45-0.79)) and fewer positive skin culture results (pooled risk ratio, RR=0.38 (95% CI=0.28-0.51)) compared with povidone iodine.Conclusion: Preoperative skin antisepsis with chlorhexidine is more effective than povidone-iodine in preventing surgical site infection. |
| Databáze: | OpenAIRE |
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