Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5' end of mRNA
| Autor: | Peter T. Lomedico, Stephen J. Mcandrew |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Preproinsulin
viruses Biology environment and public health Ribosome Start codon Eukaryotic initiation factor Translational regulation Animals Insulin RNA Messenger Protein Precursors Codon Peptide Chain Initiation Translational Genetics Messenger RNA Multidisciplinary Base Sequence Cell-Free System Mutagenesis food and beverages Rats Internal ribosome entry site Mutation Chromosome Deletion Genetic Engineering Ribosomes Proinsulin |
| Zdroj: | Nature. 299(5880) |
| ISSN: | 0028-0836 |
| Popis: | The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5' end of mRNA, appears to be important in determining initiation efficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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