Evolutionary dynamics in the fungal polarization network, a mechanistic perspective
| Autor: | Liedewij Laan, Eveline T. Diepeveen, Leila M Inigo de la Cruz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Evolutionary conservation Ecology Evolution Biophysics Fungi Review Biology Conserved sequence Evolvability 03 medical and health sciences 030104 developmental biology Order (biology) Fungal Diversity Structural Biology Evolutionary biology Protein network Cell polarity Adaptation Clade Evolutionary dynamics Molecular Biology |
| Zdroj: | Biophysical Reviews |
| ISSN: | 1867-2469 1867-2450 |
| Popis: | Polarity establishment underlies proper cell cycle completion across virtually all organisms. Much progress has been made in generating an understanding of the structural and functional components of this process, especially in model species. Here we focus on the evolutionary dynamics of the fungal polarization protein network in order to determine general components and mechanistic principles, species- or lineage-specific adaptations and the evolvability of the network. The currently available genomic and proteomic screens in a variety of fungal species have shown three main characteristics: (1) certain proteins, processes and functions are conserved throughout the fungal clade; (2) orthologous functions can never be assumed, as various cases have been observed of homologous loci with dissimilar functions; (3) species have, typically, various species- or lineage-specific proteins incorporated in their polarization network. Further large-scale comparative and experimental studies, including those on non-model species representing the great fungal diversity, are needed to gain a better understanding of the evolutionary dynamics and generalities of the polarization network in fungi. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink