The Hippocampus Maps Concept Space, Not Feature Space
| Autor: | Stephanie Theves, Guillén Fernández, Christian F. Doeller |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male Neuroinformatics Computer science Concept Formation Feature vector Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Spatial Behavior Hippocampal formation ENCODE Hippocampus Language in Interaction 03 medical and health sciences 0302 clinical medicine Concept space Concept learning 130 000 Cognitive Neurology & Memory Humans Research Articles Spatial Memory 030304 developmental biology 0303 health sciences business.industry General Neuroscience Pattern recognition Magnetic Resonance Imaging Knowledge acquisition Categorization Female Artificial intelligence business 120 Memory and Space 030217 neurology & neurosurgery Coding (social sciences) |
| Zdroj: | Journal of Neuroscience The Journal of Neuroscience, 40, 38, pp. 7318-7325 The Journal of Neuroscience J Neurosci The Journal of Neuroscience, 40, 7318-7325 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.0494-20.2020 |
| Popis: | The hippocampal formation encodes maps of space and a key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial, conceptual information. Previous work demonstrated directional coding during navigation through a continuous stimulus feature space as well as mapping of distances in a feature space that was relevant for concept learning. Here we provide the first unambiguous evidence for a hippocampal representation of the actual concept space, by showing that the hippocampal distance signal selectively reflects the mapping of specifically conceptually relevant rather than of all feature dimensions. During fMRI scanning of 32 human participants (21 females), we presented every-day objects, which had beforehand been associated with specific values on three continuous feature dimensions. Crucially, only two dimensions were relevant to prior concept learning. We find that hippocampal responses to the objects reflect their relative distances in a space defined along conceptually relevant dimensions as compared to distances in a space defined along all feature dimensions. These findings suggest that the hippocampus supports knowledge acquisition by dynamically encoding information in a space spanned along dimensions that are relevant in relation to define concepts. Statement of significance How are neural representations of conceptual knowledge organized, such that humans are able to infer never experienced relations or categorize new exemplars? Map-like representations as supported by the hippocampal formation to encode physical space during navigation have been suggested as a suitable format. Here we provide the first evidence for a hippocampal representation of a conceptual space as compared to a general feature-based space. |
| Databáze: | OpenAIRE |
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