Clinical and socio-demographic predictors for virologic failure in rural Southern Africa: preliminary findings from CART-1
| Autor: | Olatunbosun Faturyiele, Jochen Ehmer, Joëlle Bader, Molisana Cheleboi, Mokete M Motlatsi, Mojakisane Ramoeletsi, Thomas Klimkait, Mashaete Kamele, Daniel Puga, Niklaus Daniel Labhardt, Thabo Ishmael Lejone |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
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medicine.medical_specialty Univariate analysis Pathology Multivariate analysis business.industry Public Health Environmental and Occupational Health Odds ratio medicine.disease Logistic regression Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Poster Sessions – Abstract P134 Internal medicine Cohort medicine business Viral load |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| Popis: | Introduction : In 2013, the World Health Organization (WHO) recommended scaling up of routine viral load (VL) monitoring for patients on antiretroviral therapy (ART) in resource-limited settings [1]. During the transition phase from no VL-testing at all to routine VL-monitoring, targeted VL for groups at particular risk of virologic failure (VF) may be an option [2]. We present socio-demographic and clinical risk factors for VF in a cohort in rural Lesotho with no access to VL prior to the study. Materials and Methods : Data derive from a cross-sectional study providing multi-disease screening as well as VL testing to adult patients (≥16 years old) on first-line ART ≥6 months [3]. VF was defined as VL≥1000 copies/mL. Assessed potential predictors of VF were: (1) socio-demographic (sex, age, wealth-quintile, education, employment status, disclosure of HIV status to environment, travel-time to facility); (2) treatment history (history of treatment interruption >2 days, previous drug substitution within first-line ART, time on ART, ART-base and -backbone); (3) adherence (pill count) and (4) clinical (clinical or immunological failure as defined by WHO guidelines [1], presence of papular pruritic eruption (PPE)). All variables with association to VF in univariate analysis were included in a multivariate logistic regression reporting adjusted Odds ratios (aOR). Results : Data from 1,488 patients were analyzed. Overall VF-prevalence was 6.9% (95% CI 5.7–8.3). In univariate analysis, the following were associated with VF: age |
| Databáze: | OpenAIRE |
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