Permanent consequences in Langerhans cell histiocytosis patients: A pilot study from the Histiocyte Society?Late Effects Study Group
| Autor: | Cecilia Bernstrand, Gritta Janka-Schaub, Kenneth L. McClain, Jorge Braier, Riccardo Haupt, Vasanta Nanduri, Maria Grazia Calevo, Guadalupe Rey, Valerie Broadbent, R. Maarten Egeler |
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| Rok vydání: | 2004 |
| Předmět: |
Pediatrics
medicine.medical_specialty Adolescent Hearing loss Pilot Projects Bone and Bones Langerhans cell histiocytosis Prevalence medicine Humans Child Hearing Loss Societies Medical Histiocyte Probability Retrospective Studies business.industry Data Collection Incidence (epidemiology) Infant Neoplasms Second Primary Retrospective cohort study Hematology medicine.disease Surgery Histiocytosis Langerhans-Cell Histiocytosis Oncology Child Preschool Pediatrics Perinatology and Child Health Diabetes insipidus medicine.symptom Complication business Diabetes Insipidus Follow-Up Studies |
| Zdroj: | Pediatric Blood & Cancer. 42:438-444 |
| ISSN: | 1545-5017 1545-5009 |
| Popis: | Background Permanent consequences (PC) are often described among subjects with Langerhans cell histiocytosis (LCH) but data on the real incidence are scarce. Within the Histiocyte Society (HS), and in order to design a definitive late effects study, a retrospective survey was organized to describe the prevalence of PC among long-term survivors of LCH. Methods Nine institutions contributed with their LCH patients having a minimum follow-up of 3 years. Information was collected on their disease-history, and on type and date of onset of any PC. Because of the retrospective type of this study, it was accepted that each institution might have used different criteria to assess PC. Results One hundred eighty-two subjects were registered and in 95 (52%) at least 1 PC was reported. For some specific PC (e.g., anterior pituitary dysfunction) information was too scarce to provide reliable data. PC were more frequent among subjects with multisystem (MS) disease (71%), compared to those with single system (SS) disease (24%); P |
| Databáze: | OpenAIRE |
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