Metal-, Photocatalyst-, and Light-Free Minisci C–H Acetylation of N-Heteroarenes with Vinyl Ethers
| Autor: | Jianhua Liu, Qingmin Wang, Yuxiu Liu, Jianyang Dong, Hongjian Song |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Organic Chemistry Raw material 010402 general chemistry Electrocatalyst 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Metal Acetylation visual_art Reagent visual_art.visual_art_medium Photocatalysis Molecule Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 23:4374-4378 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c01310 |
| Popis: | Herein, we report a mild, operationally simple method for Minisci C-H acetylation of N-heteroarenes using vinyl ethers as robust, inexpensive acetyl sources. The reactions do not require a conventional photocatalysis, electrocatalysis, metal catalysis, light activation, or high temperature. This method is thus significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation. This protocol can be expected to obtain medically relevant molecules from abundant feedstock materials. |
| Databáze: | OpenAIRE |
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