Regular consumption of 'Nkui', a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
| Autor: | Télesphore Benoît Nguelefack, Dieudonné Njamen, Liselotte Krenn, Derek Tantoh Ndinteh, Marie Alfrede Mvondo, Edwige Nana Tchoupang, Stéphane Zingue, Sylvin Benjamin Ateba |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ovariectomy Osteoporosis chemistry.chemical_element 030204 cardiovascular system & hematology Calcium medicine.disease_cause Cardiovascular System 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Animals Humans Medicine Rats Wistar medicine.diagnostic_test Plant Extracts business.industry Estrogens Lipid metabolism medicine.disease Malondialdehyde Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Endocrinology Complementary and alternative medicine chemistry Ovariectomized rat Female Phytoestrogens business Lipid profile Oxidative stress |
| Zdroj: | Journal of Complementary and Integrative Medicine. 18:535-544 |
| ISSN: | 1553-3840 2194-6329 |
| Popis: | Objectives There is a growing body of evidence indicating the potential of culinary herbs and spices to decrease the incidence of several chronic diseases or conditions. Because of this, the WHO recommends their regular consumption. In the Cameroonian culinary practices, “Nkui” is a famous dish made from a mixture of 10 spices. In our previous study, the ethanolic extract of this mixture exhibited promising estrogenic properties. Thus, this study aimed to evaluate its protective effects on some menopause-related cardiovascular and bone disorders. Methods For this purpose, a post-menopause-like model (ovariectomized rats) has been used. Animals were orally treated with the “Nkui” extract for 60 days. The investigation focused on the oxidative stress status, endothelial function (NO bioavailability), lipid profile, and bone mass, biochemical (calcium and inorganic phosphorus contents, serum alkaline phosphatase activity) and histomorphological features. Results The extract regulated lipid metabolism in a way to prevent accumulation of abdominal fat, gain in body weight and increased atherogenic indexes induced by ovariectomy. It prevented menopause-related low levels of nitric oxide and oxidative stress damage by increasing superoxide dismutase and catalase activities, while reducing glutathione and malondialdehyde levels in the heart and aorta. Moreover, it prevented ovariectomy-induced bone mass loss, bone marrow disparities and the disorganization of the trabecular network. It also increased femur calcium and inorganic phosphorus contents. Conclusions These results suggest that a regular consumption of “Nkui” may have health benefits on cardiovascular system and osteoporosis, major health issues associated with menopause. |
| Databáze: | OpenAIRE |
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