Evaluation of Anthropometric and Metabolic Parameters in Obstructive Sleep Apnea
| Autor: | Fatma Yilmaz Aydin, Gokhan Kirbas, Zülfükar Yilmaz, Mehmet Güven, Süreyya Yilmaz, Ali Veysel Kara, Yasar Yildirim, Alpaslan Kemal Tuzcu, Faruk Kılınç |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male Pulmonary and Respiratory Medicine medicine.medical_specialty Waist Article Subject Hydrocortisone Polysomnography Risk Factors Internal medicine medicine Humans Body Weights and Measures Glycated Hemoglobin lcsh:RC705-779 Sleep Apnea Obstructive medicine.diagnostic_test business.industry Sleep apnea lcsh:Diseases of the respiratory system General Medicine Middle Aged medicine.disease Obesity nervous system diseases respiratory tract diseases Obstructive sleep apnea Endocrinology Dexamethasone suppression test Female business Body mass index Research Article medicine.drug |
| Zdroj: | Pulmonary Medicine, Vol 2015 (2015) Pulmonary Medicine |
| ISSN: | 2090-1844 2090-1836 |
| Popis: | Aims. Sleep disorders have recently become a significant public health problem worldwide and have deleterious health consequences. Obstructive sleep apnea (OSA) is the most common type of sleep-related breathing disorders. We aimed to evaluate anthropometric measurements, glucose metabolism, and cortisol levels in patients with obstructive sleep apnea (OSA).Materials and Methods. A total of 50 patients with a body mass index ≥30 and major OSA symptoms were included in this study. Anthropometric measurements of the patients were recorded and blood samples were drawn for laboratory analysis. A 24-hour urine sample was also collected from each subject for measurement of 24-hour cortisol excretion. Patients were divided equally into 2 groups according to polysomnography results: control group with an apnea-hypopnea index (AHI) n=25) and OSA group with an AHI ≥5 (n=25).Results. Neck and waist circumference, fasting plasma glucose, HbA1c, late-night serum cortisol, morning serum cortisol after 1 mg dexamethasone suppression test, and 24-hour urinary cortisol levels were significantly higher in OSA patients compared to control subjects. Newly diagnosed DM was more frequent in patients with OSA than control subjects (32% versus 8%,p=0.034). There was a significant positive correlation between AHI and neck circumference, glucose, and late-night serum cortisol.Conclusions. Our study indicates that increased waist and neck circumferences constitute a risk for OSA regardless of obesity status. In addition, OSA has adverse effects on endocrine function and glucose metabolism. |
| Databáze: | OpenAIRE |
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