Sequelae of tick-borne encephalitis in retrospective analysis of 1072 patients
| Autor: | Joanna Zajkowska, Piotr Czupryna, Maciej Kondrusik, Anna Matosek, Sławomir Pancewicz, Sambor Grygorczuk, Anna Moniuszko-Malinowska, Katarzyna Krawczuk, Justyna Dunaj |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Epidemiology 030231 tropical medicine Disease Encephalitis Viruses Tick-Borne 03 medical and health sciences 0302 clinical medicine Risk Factors Prevalence medicine Humans CSF albumin Retrospective Studies Original Paper business.industry Mental Disorders Medical record Tick-borne encephalitis Meningoencephalitis Middle Aged medicine.disease Vaccination Infectious Diseases Female Poland Nervous System Diseases business Encephalitis Tick-Borne 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268818002005 |
| Popis: | Tick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe. The aim of the study was to evaluate sequelae and to analyse the potential risk factors predisposing to sequelae development. We performed a retrospective analysis of medical records of 1072 patients who received a 1-month follow-up appointment after hospital discharge. Medical data, such as patients’ age, gender, place of living, subjective complaints, neurological and psychiatric sequelae were evaluated twice: at the moment of discharge and at follow-up visits 1 month after discharge. We observed that sequelae may affect 20.6% of TBE patients. Subjective sequelae were more frequent than subjective complaints during the hospitalisation (P < 0.001), while objective neurological symptoms during the hospitalisation were more pronounced than neurological sequelae (P < 0.001). Patients with meningoencephalomyelitis were predisposed to neurological complications, while subjective symptoms were more common in meningoencephalitis. Independent risk factors for sequelae development were: age and cerebrospinal fluid (CSF) protein concentration. The risk of late neurological complications persisting was increased in patients with higher CSF protein concentration. Based on the results of our study we concluded that, there is a need for a better vaccination program, which would prevent the development of sequelae. |
| Databáze: | OpenAIRE |
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