Chronic Lymphocytic Leukemia with an Interfollicular Architecture: Avoiding Diagnostic Confusion with Monocytoid B-cell Lymphoma
| Autor: | Volker Diehl, M. Schwonzen, Doyen T. Nguyen, Herbert Bohlen, Lawrence W. Diamond |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Lymphoma B-Cell Biopsy Chronic lymphocytic leukemia Lymphoproliferative disorders Lymphocytosis Immunophenotyping Diagnosis Differential hemic and lymphatic diseases medicine Humans Diagnostic Errors Lymph node Aged business.industry Hematology Middle Aged medicine.disease Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell Lymphoma medicine.anatomical_structure Oncology Female Lymph Nodes Lymph Bone marrow CD5 business |
| Zdroj: | Leukemia & Lymphoma. 18:179-184 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199509064940 |
| Popis: | Certain low grade B-cell lymphoproliferative disorders can be mistaken for each other morphologically, particularly when there is partial lymph node involvement. We encountered two cases of chronic lymphocytic leukemia, in which the interfollicular growth pattern and the pale appearance of the neoplastic proliferation in the lymph nodes led to a misclassification as monocytoid B-cell lymphoma. The correct diagnosis was established, however, when the lymph node morphology was carefully reexamined, with the knowledge of the clinical history, peripheral blood findings, and bone marrow data. The immunophenotype of the neoplastic cells in the peripheral blood (CD5, CD23, weak fluorescence intensity of surface immunoglobulin and CD22) and the lymph node immunohistochemistry (weak L26 staining, strong MT1 positivity) confirmed the diagnosis of chronic lymphocytic leukemia. These two cases demonstrate the necessity of a systematic approach to lymph node morphology and the utility of a multiparameter approach in the diagnosis of lymphoproliferative disorders. |
| Databáze: | OpenAIRE |
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