Changes in atrial biopsies in chronic rheumatic heart disease. II: Muscle fibre reaction
| Autor: | Dastur Dk, Daya K. Manghani, Nemish A. Shah, Shirin C. Vevaina |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Myofilament Pathology medicine.medical_specialty Adolescent Biopsy Heart Valve Diseases Degeneration (medical) Mitochondrion Cell junction Pathology and Forensic Medicine Lipofuscin Medicine Humans Heart Atria Child Subclinical infection Tricuspid valve business.industry Myocardium Rheumatic Heart Disease Cell Biology Middle Aged medicine.anatomical_structure business Myofibril |
| Zdroj: | Pathology, research and practice. 179(6) |
| ISSN: | 0344-0338 |
| Popis: | Summary Myocardial fibres were studied in the right atrial biopsies from 32 patients with chronic rheumatic heart disease, (RHD). Paraffin and, particularly, araldite sections showed many muscle fibres well preserved, and others with large hyperchromatic nuclei, or with depleted myofibrils and increased mitochondria. With the SDH and ATPase reactions, there was no type difference in the myocardial fibres, and the former showed the reaction predominantly in the centre while the latter showed it mainly at the periphery of the fibres. At electronmicroscopy, fibres with intact myofibrils were found close to “degenerating” fibres with variable degrees of myofibrillar and myofilament disorganisation and loss, mitochondrial proliferation, occasionally with degeneration of cristae, and accumulation of lipofuscin in varying amounts, and irregularly tortuous or loosened intercellular junctions. This study has revealed more severe muscle changes than expected, even in the clinically less affected right atrial chamber in chronic RHD. It is speculated that this might be due to subclinical involvement of the tricuspid valve, known to be frequent in Indian patients, and the resulting “back pressure” on the right atrium might lead to changes in its myofibres. |
| Databáze: | OpenAIRE |
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