Endogenous Androgens and Sex Hormone-Binding Globulin in Women and Risk of Metabolic Syndrome and Type 2 Diabetes
| Autor: | Stefan Gross, Henry Völzke, Matthias Nauck, Henri Wallaschofski, Brian G. Keevil, Marcus Dörr, Georg Brabant, Benjamin Fenske, Robin Haring, Hanna Kische |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Risk medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Type 2 diabetes Biochemistry Young Adult Endocrinology Sex hormone-binding globulin Internal medicine Germany Sex Hormone-Binding Globulin medicine Prevalence Humans Testosterone Longitudinal Studies Aged Aged 80 and over Metabolic Syndrome biology Free androgen index business.industry Incidence Biochemistry (medical) Age Factors Androstenedione Type 2 Diabetes Mellitus Middle Aged medicine.disease Postmenopause Cross-Sectional Studies Diabetes Mellitus Type 2 Premenopause Study of Health in Pomerania biology.protein Androgens Female Metabolic syndrome business Follow-Up Studies |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 100(12) |
| ISSN: | 1945-7197 |
| Popis: | The association of endogenous androgens and sex hormone-binding globulin (SHBG) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) mostly 23562 refers to small and selected study samples with immunoassay-based measurements. Thus, we investigated the association of hormone levels with MetS and T2DM in women from a large population-based sample.A total of 2077 women from the Study of Health in Pomerania were assessed at baseline (N = 3160, 1997-2001) and 5-year follow-up (N = 1711, 2002-2006).We investigated associations of total testosterone (T) and androstenedione measured by liquid chromatography-tandem mass spectrometry, SHBG by immunoassay, and free T and free androgen index with MetS and T2DM.Baseline prevalence of MetS and T2DM was 23.1% (N = 365) and 9.5% (N = 196), with an incidence of 17.7 and 7.0 per 1.000 person-years, respectively. Cross-sectional analyses yielded inverse associations of SHBG with MetS (relative risk [RR], 0.67; 95% confidence interval [CI], 0.60-0.74) and T2DM (RR, 0.61; 95% CI, 0.50-0.74) after multivariable adjustment. In longitudinal analyses, only age-adjusted models showed an inverse association of baseline SHBG with incident MetS (RR, 0.61; 95% CI, 0.51-0.73) and T2DM (RR, 0.58; 95% CI, 0.43-0.78). Multivariable-adjusted models stratified by menopausal status revealed an inverse association between SHBG and incident MetS risk in postmenopausal women (RR, 0.65; 95% CI, 0.51-0.81).This longitudinal population-based study revealed independent inverse associations of SHBG with MetS and T2DM, suggesting low SHBG as a potential risk marker for cardiometabolic morbidity, especially among postmenopausal women. |
| Databáze: | OpenAIRE |
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