ANTIENDOTOXIN STRATEGIES
| Autor: | J, Hellman, H S, Warren |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Lipopolysaccharides
Microbiology (medical) Membrane Glycoproteins Invertebrate Hormones Lipoproteins Membrane Proteins Blood Proteins Antibodies Bacterial Anti-Bacterial Agents Arthropod Proteins Infectious Diseases Cathelicidins Renal Dialysis Sepsis Animals Humans Carrier Proteins Gram-Negative Bacterial Infections Acute-Phase Proteins Antimicrobial Cationic Peptides Polymyxin B |
| Zdroj: | Infectious Disease Clinics of North America. 13:371-386 |
| ISSN: | 0891-5520 |
| Popis: | Endotoxin is a potent stimulator of the inflammatory response and is believed to initiate the pathology in Gram-negative sepsis. Agents are being developed that bind and neutralize or block the effects of endotoxin, with the goal of improving outcome in the treatment of sepsis. Strategies discussed in this article include anti-LPS antibodies, LPS binding proteins and lipoproteins, polymyxin B conjugates, lipid A analogues, and extracorporeal techniques for endotoxin removal. |
| Databáze: | OpenAIRE |
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