Prognostic value of contrast-enhanced MR mammography in patients with breast cancer
| Autor: | Monika Korabiowska, Ulrich Brinck, Alfred Schauer, Uwe Fischer, Lars Kopka, Eckhardt Grabbe |
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| Rok vydání: | 1997 |
| Předmět: |
Gadolinium DTPA
medicine.medical_specialty Receptor ErbB-2 Contrast Media Breast Neoplasms Gadolinium Metastasis Breast cancer Biomarkers Tumor Organometallic Compounds Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Breast Grading (tumors) Neuroradiology medicine.diagnostic_test business.industry Magnetic resonance imaging Interventional radiology General Medicine Pentetic Acid Prognosis medicine.disease Immunohistochemistry Magnetic Resonance Imaging ErbB Receptors Radiography Ki-67 Antigen Lymphatic Metastasis Female Histopathology Radiology Tumor Suppressor Protein p53 business |
| Zdroj: | European Radiology. 7:1002-1005 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | The objective of this study was to evaluate the prognostic value of contrast-enhanced MR mammography in patients with breast cancer. A total of 190 patients with breast cancer (37 noninvasive carcinomas, 153 invasive carcinomas) underwent dynamic contrast-enhanced MR mammography preoperatively. Using 1.5-T unit, T1-weighted sequences (2D FLASH) were obtained repeatedly one time before and five times after IV administration of 0.1 mmol gadopentetate-dimeglumine per kilogram body weight. The findings on MR imaging were correlated with histopathologically defined prognostic factors (histological type, tumor size, tumor grading, metastasis in lymph nodes). In addition, immunohistochemically defined prognostic factors (c-erbB-1, c-erbB-2, p53, Ki-67) were correlated with the signal increase on MR mammogram in 40 patients. There was no significant correlation between the findings on MR mammography and the histopathological type of carcinoma, the grading, and the lymphonodular status. Noninvasive carcinomas showed a higher rate of moderate (38 %) or low (27 %) enhancement on MR imaging than invasive carcinomas (6 and 3 %). The results on MR mammography and the results of immunohistochemical stainings did not correlate significantly. Noninvasive carcinomas showed significantly lower enhancement than invasive carcinomas. However, the signal behavior of contrast-enhanced MR mammography is not related to established histopathological prognostic parameters as subtyping, grading, nodal status, and the expression of certain oncogenes/tumor suppressor genes. |
| Databáze: | OpenAIRE |
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