Anti-Glycated Albumin Therapy Ameliorates Early Retinal Microvascular Pathology in db/db Mice
| Autor: | Margo P. Cohen, Rex S. Clements, W. Gerald Robison |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Glycosylation Endocrinology Diabetes and Metabolism Basement Membrane Retina Diabetic nephropathy Pathogenesis Mice Endocrinology Mice Inbred NOD Glycation Internal medicine Diabetes mellitus Internal Medicine medicine Animals Glycated Serum Albumin Serum Albumin Diabetic Retinopathy business.industry Microangiopathy Albumin Antibodies Monoclonal Retinal Vessels Diabetic retinopathy medicine.disease Immunohistochemistry Microscopy Electron Diabetes Mellitus Type 1 business Retinopathy |
| Zdroj: | Journal of Diabetes and its Complications. 12:28-33 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(97)00051-2 |
| Popis: | Hyperglycemia plays a primary causal role in the early vascular damage leading to diabetic retinopathy, but the intermediate biochemical mechanisms involved are not known. Because albumin modified by Amadori glucose adducts has been implicated in the pathogenesis of diabetic nephropathy, we investigated whether or not glycated albumin plays a similar role in diabetic retinopathy. We observed basement membrane thickening and an accumulation of basement membrane material in the capillaries of the outer plexiform layer of retinae from diabetic db/db mice compared with their nondiabetic db/m littermates. Both of these abnormalities were ameliorated by chronic (8 week) treatment with monoclonal antibodies that specifically recognize Amadori-modified glycated albumin (and not other glucose-modified or advanced glycation endproducts-modified proteins), despite the fact that the administration of these antibodies did not alter the glycemic status of the diabetic animals. Thus, albumin containing Amadori glucose adducts contributes to the pathogenesis of diabetic retinal vascular disease, and agents that neutralize or prevent the formation of excess glycated albumin in diabetes may offer prophylaxis against the early changes of diabetic retinopathy. |
| Databáze: | OpenAIRE |
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