The combination of several antidepressants is not synergistic on the firing of lateral septal neurons in the rat
| Autor: | Margarita Saavedra, Carlos M. Contreras, Miguel Molina-Hernández, Dolores Beltrán |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Clomipramine medicine.medical_treatment Central nervous system Rhinencephalon Electroconvulsive therapy Internal medicine medicine Animals Rats Wistar Electroconvulsive Therapy Biological Psychiatry Pharmacology business.industry Drug Synergism medicine.disease Privation Antidepressive Agents Rats Electrophysiology Sleep deprivation Endocrinology medicine.anatomical_structure Mechanism of action Sleep Deprivation Septal Nuclei medicine.symptom business medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 19:1157-1162 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/0278-5846(95)00233-2 |
| Popis: | 1. 1. Three kinds of antidepressants (clomipramine, sleep deprivation and electroconvulsive shock) increase the firing rate in the lateral septal neurons of the rat. 2. 2. The acute combination of these treatments, however, did not produce added effects on firing rate of lateral septal neurons in the rat. 3. 3. 24 hours of sleep deprivation blocked the actions of a single electroconvulsive shock. 4. 4. It is concluded that the firstly applied treatment modifies the receptors sensitivity from the very beginning, thus blocking the action of a second treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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