Discordance between lipid markers used for predicting cardiovascular risk in patients with type 2 diabetes

Autor: Rajesh Chandwani, Ishaq Ahmed, K.V.S. Hari Kumar, KD Modi
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Apolipoprotein B
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Gastroenterology
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Humans
Young adult
Aged
medicine.diagnostic_test
Triglyceride
biology
business.industry
Surrogate endpoint
Cholesterol
HDL
Cholesterol
LDL
General Medicine
Middle Aged
Prognosis
medicine.disease
Lipids
Gestational diabetes
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Cardiovascular Diseases
biology.protein
Female
lipids (amino acids
peptides
and proteins)
Lipid profile
business
Biomarkers
Zdroj: Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 10:S99-S102
ISSN: 1871-4021
DOI: 10.1016/j.dsx.2015.10.002
Popis: Summary Aims Non-high density lipoprotein cholesterol (non-HDL-C) is gaining importance over low density lipoprotein cholesterol (LDL-C) as cardiovascular risk marker in patients with type 2 diabetes. It represents the overall lipid burden and is a surrogate marker for the apolipoprotein B. We studied the discordance between the old (LDL-C) and the new (non-HDL-C) lipid markers in a large group of diabetes patients. Methods The lipid profile data of all diabetes (T2DM, aged 18–75, using oral or injectable anti diabetic agents) patients was analyzed in this study. We excluded patients with type1 diabetes, secondary forms of diabetes and gestational diabetes. Elevated lipid parameters (LDL > 100 mg/dL and non HDL-C > 130 mg/dL) were defined as per the guidelines of Adult Treatment Panel III. Results The study participants (409 M:360 F) had a mean age of 47.3 ± 12.4 years, BMI of 28.4 ± 5.6 kg/m 2 and an A1c of 8.8 ± 2.2%. Elevated LDL-C was observed in 383 patients (49.8%) and elevated non HDL-C in 418 (54.4%) patients. Of the 383 patients with elevated LDL-C, 346 (90.3%) had corresponding elevated levels of non-HDL-C and out of 418 patients with elevated non HDL-C, 346 (83%) had elevated LDL-C. Discordance between the elevated LDL-C and non-HDL-C values were greater among patients with low triglyceride levels when compared with those with high triglycerides (Pearson's χ 2 test = 67.7; P Conclusion Our data suggest a significant discordance between the LDL-C and non-HDL-C in patients with diabetes. This discordance leads to the residual cardiovascular risk in diabetes patients.
Databáze: OpenAIRE
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