| Autor: |
Mulder, M.B., Hoek, B. van, Berg, A.P. van den, Polak, W.G., Alwayn, I.P.J., Jong, K.P. de, Winter, B.C.M. de, Verhey-Hart, E., Erler, N.S., Hoed, C.M. den, Metselaar, H.J. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Liver Transplantation, 29(2), 184-195. WILEY |
| Popis: |
The aim of this study was to investigate whether the combination of low-dose sirolimus (SRL) and low-dose extended-release tacrolimus (TAC) compared to normal-dose extended-release TAC results in a difference in the renal function and comparable rates of rejection, graft and patient survival at 36 months after transplantation. This study was an open-label, multicenter randomized, controlled trial. Patients were randomized to once-daily normal-dose extended-release TAC (control group) or once-daily combination therapy of SRL and low-dose extended-release TAC (interventional group). The primary endpoint was the cumulative incidence of chronic kidney disease (CKD) defined as grade >= 3 (estimated glomerular filtration rate (eGFR) = 3 at 36 months compared to normal-dose extended-release TAC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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