Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects
| Autor: | J.M. van Laar, W M Zuijderduin, W Wouters-Wesseling, F. C. Breedveld, A Jongma, Jacob K. Sont, Phj Remans, L W Wagenaar |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Docosahexaenoic Acids Medicine (miscellaneous) Pain Ascorbic Acid Gastroenterology Antioxidants Arthritis Rheumatoid chemistry.chemical_compound Double-Blind Method Internal medicine Fatty Acids Omega-6 Fatty Acids Omega-3 medicine Humans Vitamin E Micronutrients gamma-Linolenic Acid Unsaturated fatty acid chemistry.chemical_classification Nutrition and Dietetics Hand Strength business.industry Fatty acid Middle Aged Micronutrient Eicosapentaenoic acid Surgery Treatment Outcome chemistry Eicosapentaenoic Acid Docosahexaenoic acid Dietary Supplements Fatty Acids Unsaturated Arachidonic acid Female Docosapentaenoic acid business Polyunsaturated fatty acid |
| Zdroj: | European journal of clinical nutrition. 58(6) |
| ISSN: | 0954-3007 |
| Popis: | Objective To investigate in a double-blind placebo-controlled, parallel group study, the effects of a nutrient supplement, containing, among other ingredients, the omega-3 fatty acids eicosapentaenoic acid (1.4 g EPA), docosahexaenoic acid (0.211 g DHA), omega-6 fatty acid gamma-linolenic acid (0.5 g GLA) and micronutrients in patients with active rheumatoid arthritis (RA). Design, subjects and intervention RA patients were randomized to receive either daily liquid nutrient supplementation or placebo for 4 months. The primary end point was the change in tender joint count at 2 and 4 months. Other clinical variables included swollen joint count, visual analogue scales for pain and disease activity, grip strength, functionality score and morning stiffness. Biochemical parameters included plasma concentrations of PUFA and vitamins C and E. Setting Outpatient university clinic. Results In all, 66 patients enrolled, 55 completed the study. No significant change from baseline in tender joint count or any of the other clinical parameters was detected in either group. Patients receiving nutrient supplementation, but not those receiving placebo, had significant increases in plasma concentrations of vitamin E (P=0.015), and EPA, DHA and docosapentaenoic acid concomitant with decreases of arachidonic acid (P=0.01). Intergroup differences for PUFA and vitamin E were significantly different (P=0.01 and 0.03, respectively). Conclusions This double-blind, placebo-controlled study in RA patients did not show superior clinical benefit of daily nutrient supplementation with EPA, GLA and micronutrients at the doses tested as compared to placebo. The study adds information regarding doses of omega-3 fatty acids, below which anti-inflammatory effects in RA are not seen. |
| Databáze: | OpenAIRE |
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