Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in {SARS}-{CoV}-2 infected patients: a single center study
| Autor: | Francesco Buccisano, Daniela Fraboni, Elisabetta Teti, Andrea Di Lorenzo, Marco Iannetta, Massimo Andreoni, Vincenzo Malagnino, Angela Crea, Marta Zordan, Laura Campogiani, Raffaele Palmieri, Ilaria Spalliera, Pietro Vitale, Benedetta Rossi, Maria Teresa Voso, Loredana Sarmati |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Science Rome CD8-Positive T-Lymphocytes Single Center Logistic regression Predictive markers Gastroenterology Severity of Illness Index Article Settore MED/06 03 medical and health sciences 0302 clinical medicine T-Lymphocyte Subsets Internal medicine Nasopharynx Severity of illness Medicine Humans 030212 general & internal medicine Hospital Mortality Lymphocyte Count Aged Retrospective Studies Aged 80 and over Multidisciplinary business.industry Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 COVID-19 Retrospective cohort study T lymphocyte Middle Aged Peripheral 030104 developmental biology Risk factors Peripheral blood lymphocyte Female business Infection CD8 |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| Popis: | The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4− CD8− double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p |
| Databáze: | OpenAIRE |
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