Chronic urticaria, arthralgia, raised erythrocyte sedimentation rate and IgG paraproteinaemia: a variant of Schnitzler's syndrome?
| Autor: | D. Nashan, Cord Sunderkötter, T. A. Luger, S. Goerdt, Gisela Bonsmann |
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| Rok vydání: | 2006 |
| Předmět: |
Urticaria
business.industry Raised erythrocyte sedimentation rate Paraproteinemias Histology Blood Sedimentation Syndrome Dermatology Middle Aged medicine.disease Arthralgia Pathophysiology Schnitzler syndrome Immunoglobulin G Gammopathy Immunopathology Chronic Disease Immunology medicine Humans Female Paraproteins business Chronic urticaria |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1995.tb02507.x |
| Popis: | Schnitzler's syndrome is a distinct disease entity characterized by the association of chronic urticaria, intermittent fever, arthralgia, elevated erythrocyte sedimentation rate and IgM macroglobulinaemia. We report a patient with the same symptoms, but a monoclonal IgG instead of IgM gammopathy. Histological examination of the urticarial lesions showed signs of mild leucocytoclastic vasculitis. Except for the different class of the monoclonal immunoglobulin, the clinical symptoms, laboratory findings and histology in this patient were identical with those in classical Schnitzler's syndrome. IgG and IgM paraproteins may be equivalent with regard to the putative pathophysiology of the disease process in Schnitzler's syndrome. We therefore suggest that the spectrum of Schnitzler's syndrome is expanded to include patients with chronic urticaria and monoclonal IgG gammopathy, as a closely related variant. |
| Databáze: | OpenAIRE |
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