Comparison of collagen matrix treatment impregnated with platelet rich plasma vs bone marrow
| Autor: | Hitomi Sano, Ai Minamimura, Naomi Sekiya, Shigeru Ichioka |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin wound Wound size Less invasive Neovascularization Physiologic Matrix (biology) Mice Animals Humans Medicine Aged Bone Marrow Transplantation Wound Healing Tissue Scaffolds Platelet-Rich Plasma business.industry Microcirculation Anatomy Middle Aged Autologous bone Diabetic Foot medicine.anatomical_structure Platelet-rich plasma Female Surgery Collagen Bone marrow Wound healing business |
| Zdroj: | Journal of Plastic Surgery and Hand Surgery. 48:15-20 |
| ISSN: | 2000-6764 2000-656X |
| DOI: | 10.3109/2000656x.2013.793193 |
| Popis: | This study has reported the efficacy of an autologous bone marrow-impregnated collagen matrix experimentally and clinically. Then, it reflected that platelet rich plasma (PRP) was as good a source of growth factors as bone marrow and available in a less invasive procedure. This study aimed to compare the efficacy of a PRP-impregnated collagen matrix with that of a bone marrow-impregnated collagen matrix by quantifying wound size and capillary density using genetically diabetic db/db mice. Bone marrow cells were obtained from femurs of ddy mice. Then, a small amount of collagen matrix was immersed in bone marrow suspension. This is called a bone marrow-impregnated collagen matrix. PRP was obtained from healthy human blood and a small amount of collagen matrix was immersed in PRP. This is called a PRP-impregnated collagen matrix. A bone marrow-impregnated collagen matrix and PRP-impregnated collagen matrix were applied to excisional skin wounds on a genetically healing-impaired mouse (n = 6) and wounds were evaluated 6 days after the procedure. Wounds were divided into two groups: PRP (n = 6), in which a PRP-impregnated collagen matrix was applied; and bone marrow (n = 6), in which collagen immersed in a bone marrow suspension was applied. There was no significant difference between the PRP and bone-marrow groups in the rate of vascular density increase or wound size decrease. The present study suggested that the PRP-impregnated collagen matrix promotes repair processes at least as strongly as the bone marrow-impregnated collagen matrix. Given lower invasiveness, the PRP-impregnated collagen matrix would have advantages in clinical use. |
| Databáze: | OpenAIRE |
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