Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes
| Autor: | Józef Hurek, Paweł Kafarski, Weronika Wanat, Michał Talma, Małgorzata Pawełczak |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular aminophosphonates Molecular model Stereochemistry Phosphorous Acids Glycine Phenylalanine ammonia-lyase 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Ammonia chemistry.chemical_compound Structure-Activity Relationship PAL inhibitors Enzyme Inhibitors Phenylalanine Ammonia-Lyase Solanum tuberosum chemistry.chemical_classification biology molecular modeling 010405 organic chemistry Active site Substrate (chemistry) General Medicine Lyase 0104 chemical sciences Enzyme chemistry biology.protein |
| Zdroj: | Biochimie. 151 |
| ISSN: | 1638-6183 |
| Popis: | A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato l-phenylalanine ammonia lyase. Most of the compounds appeared to act as moderate (micromolar) inhibitors of the enzyme. Analysis of their binding performed using molecular modeling have shown that they might be bound either in active site of the enzyme or in the non-physiologic site. The latter one is located in adjoining deep site nearby the to the entrance channel for substrate into active site. |
| Databáze: | OpenAIRE |
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