Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children

Autor: Ina Bergheim, Anna Janina Engstler, Ina B. Maier, Anika Nier
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Leptin
Steatosis
Physiology
Peptide Hormones
Lipopolysaccharide Receptors
lcsh:Medicine
Toxicology
Pathology and Laboratory Medicine
Biochemistry
Cytopathology
0302 clinical medicine
Endocrinology
Non-alcoholic Fatty Liver Disease
Small intestinal bacterial overgrowth
Medicine and Health Sciences
Toxins
lcsh:Science
Child
Multidisciplinary
Membrane Glycoproteins
biology
Liver Diseases
Fatty liver
Acute-phase protein
Alanine Transaminase
Genomics
Body Fluids
Blood
Medical Microbiology
030211 gastroenterology & hepatology
Female
Anatomy
Research Article
medicine.medical_specialty
Adolescent
Toxic Agents
Bacterial Toxins
Gastroenterology and Hepatology
Microbial Genomics
Microbiology
Blood Plasma
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Genetics
Humans
Lactic Acid
Inflammation
Intestinal permeability
Endocrine Physiology
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Hormones
Endotoxins
Fatty Liver
Gastrointestinal Tract
030104 developmental biology
Alanine transaminase
Anatomical Pathology
biology.protein
lcsh:Q
Microbiome
Steatohepatitis
Insulin Resistance
business
Carrier Proteins
Digestive System
Acute-Phase Proteins
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0183282 (2017)
ISSN: 1932-6203
Popis: Background & aims Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing disease or are already found in initial disease stages has not yet been clarified. Methods Twenty children with simple steatosis (grade 1) diagnosed by ultrasound and 29 normal weight healthy control children (age
Databáze: OpenAIRE