Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits
| Autor: | Naseer, Z., Ahmad, E., Aksoy, M., Epikmen, E.T. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
testes rabbit Apoptosis Rabbit medicine.disease_cause sperm Heat stress quercetin Andrology heat stress 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine heterocyclic compounds Testes Acrosome 030304 developmental biology lcsh:SF1-1100 0303 health sciences 030219 obstetrics & reproductive medicine lcsh:Veterinary medicine apoptosis Sertoli cell Epididymis Malondialdehyde Sperm medicine.anatomical_structure chemistry lcsh:SF600-1100 Animal Science and Zoology Quercetin lcsh:Animal culture Germ cell Oxidative stress |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname World Rabbit Science, Vol 28, Iss 1, Pp 19-27 (2020) |
| Popis: | [EN] The current study was designed to determine the effects of dietary quercetin on epididymal sperm and testicular changes in male rabbits during summer heat stress (HS). Twelve adult male New Zealand white rabbits were submitted to summer heat conditions (temperature-humidity index 29.9±1.2). One group was fed a basal ration (BR; n=6), whereas the other group was fed the same basal diet supplemented with quercetin (30 mg/kg d; Que-BR; n=6) for 60 d, and both groups were sacrificed at the end of the experiment. Epididymis and testicles isolation was done for sperm, histopathology and apoptosis assessments. The results showed that quercetin improved epididymis weight, but did not affect other testicular dimensions except testicular length. A significant improvement was observed in epididymal sperm motility, concentration, kinematic parameters, viability, mitochondrial potential and acrosome integrity in Que-BR compared to the BR group. Lowered serum malondialdehyde level was observed in quercetin supplemented rabbits. Moreover, the quercetin supplementation maintained the interstitial stroma, seminiferous tubules architecture, germinal and Sertoli cells under HS, decreasing the apoptotic germ cell rate in seminiferous tubules. In conclusion, HS condition affects the sperm and testes configurations in rabbits and dietary quercetin minimises oxidative stress, which in turn protects the testes and sperm against HS induced damage. The financial support for this work was granted by ADU-BAP, Project number VTF-15034, Adnan Menderes University, Aydin, Turkey. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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