Hemodynamic, hemorheologic, and hemocoagulative changes after treatment with picotamide in patients affected by peripheral arterial disease (PAD) of the lower limbs
| Autor: | L. Poli, F. Bonino, M. Neirotti, M. Ponzetto, Fabrizio Fabris, Carmine Macchione, Mario Molaschi |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Phthalic Acids Hemodynamics Arterial Occlusive Diseases 030204 cardiovascular system & hematology Placebo 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine Erythrocyte Deformability Medicine Picotamide Humans 030212 general & internal medicine Platelet activation Photoplethysmography Blood Coagulation Peripheral Vascular Diseases business.industry Vascular disease Fibrinogen Intermittent Claudication Middle Aged medicine.disease Blood Viscosity beta-Thromboglobulin Intermittent claudication Surgery Peripheral Hemorheology Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Angiology. 45(2) |
| ISSN: | 0003-3197 |
| Popis: | Effects of picotamide on platelet activity and on some hemorheologic, coagu lative, and hemodynamic parameters were investigated in a randomized, dou ble-blind, placebo-controlled study for eighteen months. Twenty patients, average age 61.5±9.6 (SD) years, with peripheral arterial disease (PAD) at functional stage 2 of the Fontaine classification and with intermittent claudica tion for at least six months were studied. Ten patients received tablets of picotamide, 300 mg three times a day, and 10 subjects received three identical placebo tablets each day. Similar atheroscler otic disease risk factors were present in both groups. Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmo graphic wave. |
| Databáze: | OpenAIRE |
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