A Comprehensive Analysis of the Stability of Blood Eosinophil Levels
| Autor: | Jochen Brumm, Bradley E. Chipps, Mona Bafadhel, Tmirah Haselkorn, Cecile T.J. Holweg, Ming Yang, Nizar N. Jarjour, William J. Calhoun, Jonathan Corren, Ahmar Iqbal |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
business.industry diagnosis eosinophil count Eosinophilic asthma Eosinophil respiratory system asthma medicine.disease Antibodies Monoclonal Humanized Patient management Eosinophils Leukocyte Count medicine.anatomical_structure Immunology medicine Humans Anti-Asthmatic Agents Pulmonary Eosinophilia business Adult Pulmonary patient management Blood eosinophil Asthma Original Research |
| Zdroj: | Annals of the American Thoracic Society |
| ISSN: | 2325-6621 |
| Popis: | Rationale: Blood eosinophil counts are used to inform diagnosis/management of eosinophilic asthma. Objectives: Examine blood eosinophil variability and identify factors affecting eosinophil levels to inform clinical interpretation. Methods: Post hoc analysis to understand eosinophil variability using data from four randomized controlled asthma trials. We examined 1) influence of intrinsic/extrinsic factors (comorbidities, medication, and patient history) using baseline data (n = 2,612); 2) monthly variation using placebo-treated patient data (n = 713); 3) stability of eosinophil classification ( |
| Databáze: | OpenAIRE |
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