EXTRACELLULAR VESCICLES DERIVED FROM GUT MICROBIOTA IN INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER
| Autor: | Giusi Alberti, Margherita Mazzola, Francesco Carini, Carola Maria Gagliardo, Marco Giammanco, Alberto Fucarini, Alessandro Pitruzzella, Giovanni Tomasello |
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| Přispěvatelé: | Alberti,G, Mazzola,M, Gagliardo,C, Pitruzzella A, Fucarini,A, Giammanco,M, Tomasello,G, Carini,F, Alberti G., Mazzola M., Gagliardo C., Pitruzzella A., Fucarini A., Giammanco M., Tomasello G., Carini F. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Colorectal cancer
Gut microbiota Gut flora Inflammatory bowel disease General Biochemistry Genetics and Molecular Biology Extracellular Vesicles Immune system Flora (microbiology) Humans Medicine Microbiome Barrier function Bacteria biology business.industry Microbiota Inflammatory Bowel Diseases medicine.disease biology.organism_classification digestive system diseases Gastrointestinal Microbiome Crosstalk (biology) Immunology colo-rectal cancer extracellular vescicles gut microbiota inflammatory bowel dsease Colorectal Neoplasms business |
| Zdroj: | Biomedical Papers, Vol 165, Iss 3, Pp 233-240 (2021) |
| Popis: | The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dys-regulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions. |
| Databáze: | OpenAIRE |
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