Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity
| Autor: | Peter D. Arkwright, M. R. Potter, Timothy J. David, Debasis Sanyal, B. D. Cookson, M. R. Haeney |
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| Rok vydání: | 2001 |
| Předmět: |
Allergy
Staphylococcus aureus Adolescent Immunology Immunoglobulin E medicine.disease_cause CD5 Antigens Lymphocyte Activation Dermatitis Atopic Atopy Enterotoxins Leukocyte Count Immune system Immunopathology Superantigen Immunology and Allergy Medicine Humans Lymphocyte Count Child B-Lymphocytes Superantigens biology business.industry Atopic dermatitis medicine.disease Eosinophils Blood Child Preschool Immunoglobulin G biology.protein Nasal Cavity business |
| Zdroj: | Clinical and experimental immunology. 125(2) |
| ISSN: | 0009-9104 |
| Popis: | SummaryToxin-positive strains of Staphylococcus aureus (T + S. aureus) are present on the skin of some but not all patients with atopic dermatitis. Many staphylococcal toxins are superantigens, which can stimulate the immune response and thus may potentially lead to the very high levels of IgE characteristic of this condition, as well as exacerbating the clinical disease. The aim of this study was to determine whether the presence of T + S. aureus on the skin of children with atopic dermatitis was associated with in vivo evidence of a heightened humoral immune response, higher IgE levels and more severe clinical disease. Toxin gene expression in S. aureus isolated from the eczematous lesions of 28 children with atopic dermatitis was assessed by PCR. Clinical and immune data were also collected from this cohort. Thirteen of the 28 children (46%) were colonized with T + S. aureus strains. The presence of T + S. aureus was associated with a significant expansion in peripheral blood CD5− B cells (P = 0·01), and the more toxin types identified the greater the B-cell expansion (P = 0·002). However, in this cohort of children with atopic dermatitis, despite th in vivo expansion of B cells in children harbouring T + S. aureus, there was no associated increase in IgE levels or in clinical disease severity scores. |
| Databáze: | OpenAIRE |
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