Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity

Autor: Mahmut Ozsahin, Jérôme Solassol, D. Azria, Muriel Brengues, Sophie Gourgou, Alain Mangé, André Pèlegrin, Céline Bourgier, Jerome Lacombe
Přispěvatelé: Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de radiothérapie, CRLCC Val d'Aurelle - Paul Lamarque, Unité de biostatistiques en Oncologie, CRLC Val d'Aurelle, Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Service de Biopathologie [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Mangé, Alain
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Proteomics
Organs at Risk
Proteome
T-Lymphocytes
medicine.disease_cause
Radiation Tolerance
chemistry.chemical_compound
0302 clinical medicine
Medicine
Breast
Prospective Studies
chemistry.chemical_classification
Superoxide
Radiation-induced breast fibrosis
NOX4
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
3. Good health
Oncology
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
AK2
lcsh:Medical physics. Medical radiology. Nuclear medicine
lcsh:R895-920
[SDV.CAN]Life Sciences [q-bio]/Cancer
Breast Neoplasms
lcsh:RC254-282
Peripheral blood mononuclear cell
Radiosensitivity
03 medical and health sciences
Adenylate Kinase/metabolism
Biomarkers/metabolism
Breast/metabolism
Breast/radiation effects
Breast Neoplasms/radiotherapy
Fibrosis/etiology
Fibrosis/metabolism
Fibrosis/pathology
Humans
Organs at Risk/radiation effects
Proteome/analysis
Radiation Injuries/etiology
Radiation Injuries/metabolism
Radiation Injuries/pathology
Radiotherapy/adverse effects
Reactive Oxygen Species/metabolism
T-Lymphocytes/metabolism
T-Lymphocytes/pathology
T-Lymphocytes/radiation effects
NADPH oxidases
Normal tissue radiotoxicity
Radiotherapy
[SDV.CAN] Life Sciences [q-bio]/Cancer
Radiology
Nuclear Medicine and imaging
Radiation Injuries
Reactive oxygen species
business.industry
Research
Adenylate Kinase
Fibrosis
chemistry
Cancer research
business
Reactive Oxygen Species
Oxidative stress
Biomarkers
Annexin A1
Zdroj: Radiation Oncology (London, England)
Radiation Oncology
Radiation Oncology, BioMed Central, 2019, 14 (1), pp.142. ⟨10.1186/s13014-019-1351-8⟩
Radiation Oncology, Vol 14, Iss 1, Pp 1-11 (2019)
Radiation oncology, vol. 14, no. 1, pp. 142
ISSN: 1748-717X
Popis: Background Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their advantages. Methods We used the isobaric tags for relative and absolute quantitation (iTRAQ) proteomic approach to analyze differences in protein expression levels in ex-vivo irradiated (8 Gy) T lymphocytes from patients with grade ≥ 2 radiation-induced breast fibrosis (grade ≥ 2 bf+) and patients with grade
Databáze: OpenAIRE
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