Chemical reporters for biological discovery
| Autor: | Howard C. Hang, Markus Grammel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Azides Molecular Structure Systems biology Biomolecule Cellular pathways Chemical biology Proteins Cell Biology Alkenes Biology Lipids Article Living systems Biological pathway Biochemistry chemistry Polysaccharides Alkynes Nucleic Acids Posttranslational modification Animals Humans Bioorthogonal chemistry Molecular Biology |
| Zdroj: | Nature Chemical Biology. 9:475-484 |
| ISSN: | 1552-4469 1552-4450 |
| Popis: | Functional tools are needed to understand complex biological systems. Here we review how chemical reporters in conjunction with bioorthogonal labeling methods can be used to image and retrieve nucleic acids, proteins, glycans, lipids and other metabolites in vitro, in cells as well as in whole organisms. By tagging these biomolecules, researchers can now monitor their dynamics in living systems and discover specific substrates of cellular pathways. These advances in chemical biology are thus providing important tools to characterize biological pathways and are poised to facilitate our understanding of human diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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