Similar age-related changes in two regions of muscle with different properties
| Autor: | P.F. Gardiner, K.L. Seburn, S. Vanden Noven, Nancy K. Latham |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Senescence
Male medicine.medical_specialty Aging Contraction (grammar) Muscle Fibers Skeletal Medial gastrocnemius Cell Count Biology Muscle Development Rats Sprague-Dawley Gastrocnemius muscle Internal medicine Age related Isometric Contraction medicine Animals Muscle Skeletal Horseradish Peroxidase Motor Neurons Histocytochemistry General Neuroscience Anatomy Muscle degeneration Motor neuron musculoskeletal system Muscle Denervation Hindlimb Rats Endocrinology medicine.anatomical_structure medicine.symptom Muscle contraction Muscle Contraction |
| Zdroj: | Neuroreport. 7(3) |
| ISSN: | 0959-4965 |
| Popis: | Two regions of the medial gastrocnemius (MG) muscle, with different contractile properties and innervated by different nerve branches, were investigated in male Sprague-Dawley rats at three ages : 2-3 months, 6-7 months and 24-25 months (i.e., the '50% survival age and beyond' : a recommended definition of aged rodents derived from lifespan data on a given colony). At the 50% survival age, both regions of the MG showed decreased mass, slowed contraction times and a decreased number of fast-twitch, but not slow-twitch, muscle fibres. The 40% loss of fast-twitch muscle fibres was not reflected in the loss of motoneurones, suggesting that muscle degeneration precedes motoneurone loss at the 50% survival age in the rat. |
| Databáze: | OpenAIRE |
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