Two year follow-up in 643 patients with non-invasively unexplained syncope and therapy guided by electrophysiologic study
| Autor: | K. Seidl, Julia C. Senges, A. Drögemüller, Monika Rameken, Ralf Zahn, Steffen Schneider |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Cardiac Catheterization medicine.medical_specialty Heart Diseases Heart disease Neurological disorder Disease Logistic regression Disease-Free Survival Syncope Diagnosis Differential Ventricular Dysfunction Left Heart Conduction System Tilt-Table Test Internal medicine medicine Electrophysiologic study Humans Survival rate Aged Ejection fraction biology business.industry Cardiac Pacing Artificial Syncope (genus) Arrhythmias Cardiac Stroke Volume Middle Aged Prognosis biology.organism_classification medicine.disease Surgery Echocardiography Electrocardiography Ambulatory Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Zeitschrift für Kardiologie. 92:852-861 |
| ISSN: | 1435-1285 0300-5860 |
| DOI: | 10.1007/s00392-003-0969-5 |
| Popis: | Although it has become standard practice to perform electrophysiologic studies in patients with unexplained syncope, limited information exists on prognosis after therapy guided by electrophysiologic studies. Electrophysiologic studies were performed in 643 patients with unexplained syncope. Electrophysiologic studies revealed conduction abnormalities and tachyarrhythmias accounting for syncope in 35% of patients. An ejection fraction ≤ 40%, a PR-interval > 2 s and injury are helpful parameters in predicting a positive electrophysiologic study. There was no difference regarding cumulative 2-year survival rate after therapy guided by positive electrophysiologic study compared to patients with negative electrophysiologic study. The cumulative 2-year survival free-of-syncope rate was significantly higher after therapy guided by electrophysiologic study compared to patients with negative electrophysiologic findings—for patients with organic heart disease (71.3% vs 48.5%, p < 0.001) and patients without disease (91.3% vs. 65.2%, p < 0.001). Using a logistic regression model, a positive electrophysiologic study was associated with a favorable outcome; multiple syncopal events or organic heart disease were associated with an unfavorable outcome. The cumulative overall 2-year surival free-of-syncope rate is significantly higher in patients after therapy guided by electrophysiologic study compared to patients with negative electrophysiologic findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink