| Popis: |
50, 150, 300 and 500 U.I. of HCG were administered to male rabbits, 20, 40, 60 and 180 days of age. Plasma and testicular testosterone were quantified by radioimmunoassay or gas chromatography 1 h after the injection. At all stages, HCG significantly increased plasma and testicular testosterone compared with saline-injected controls of the same age. Expressed as a per cent of basal level, the plasma testosterone was increased 422% at 20 days, 216% at 40 days, 386% at 60 days and 1122% at 180 days. The content and concentration of testosterone in the testes were increased 485 and 366% at 20 days, 378 and 517% at 40 days, 244 and 107% at 60 days, 1062 and 1106% at 180 days. At all stages studied, the response of the immature testis was much less than that in adults. It did not increase between 20 and 60 days. |
