Syntheses of oligomannosides in solution and on a soluble polymer support: a comparison
| Autor: | Richard H. Furneaux, Michael Ludewig, Regine Blattner |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Polymers Chemistry Molecular Sequence Data Organic Chemistry Oligosaccharides Glycoside Soluble polymer General Medicine Solution synthesis Oligosaccharide Biochemistry Polyethylene Glycols Analytical Chemistry Solutions Carbohydrate Sequence Yield (chemistry) Carbohydrate Conformation Organic chemistry |
| Zdroj: | Carbohydrate Research. 341:299-321 |
| ISSN: | 0008-6215 |
| DOI: | 10.1016/j.carres.2005.11.027 |
| Popis: | The α-(1→6)-linked and the α-(1→2)-linked linear mannotetraose glycosides 3 and 4 , respectively, and the branched mannopentaoside 2 [R = CH 2 (CH 2 ) 2 CH 2 Cl] were synthesised by conventional methods in solution, using trichloroacetimidate donors, and the products were obtained in 39%, 42% and 40% overall yield, respectively. For comparative purposes, the same two linear tetrasaccharides were prepared by use of MPEG as a soluble polymer support, the yields being 34% and 14%, respectively. An attempted MPEG-supported synthesis of the branched pentasaccharide was unsuccessful. The merits and shortcomings of oligosaccharide syntheses on MPEG are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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