Differential Expression of Rat Brain Bcl-2 Family Proteins in Development and Aging
| Autor: | Sadaki Fujimoto, Yasuo Sumida, Hiroko Tanino, Shun Shimohama |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Aging medicine.medical_specialty bcl-X Protein Biophysics Biology Biochemistry Gene product Fetus Bcl-2-associated X protein Downregulation and upregulation Proto-Oncogene Proteins Internal medicine medicine Animals Rats Wistar Molecular Biology B cell bcl-2-Associated X Protein Cerebral Cortex Bcl-2 family Brain Gene Expression Regulation Developmental Membrane Proteins Cell Biology Rats bcl-2 Homologous Antagonist-Killer Protein medicine.anatomical_structure Endocrinology Proto-Oncogene Proteins c-bcl-2 Membrane protein biology.protein bcl-Associated Death Protein Carrier Proteins Bcl-2 Homologous Antagonist-Killer Protein |
| Zdroj: | Biochemical and Biophysical Research Communications. 252:92-96 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1998.9577 |
| Popis: | We have previously examined the involvement of the B cell leukemia-2 gene product (Bcl-2) family proteins (Bcl-2, Bcl-x, Bax, Bak, and Bad) in Alzheimer's disease (AD) and found that Bcl-2, Bcl-x, Bak, and Bad were upregulated. As AD is an aging-associated disease, in the present study we examined the developmental and aging-related changes in Bcl-2 family proteins in the rat brain. Immunoblot analyses of brain extracts from embryonic day 19 (E19) to postnatal 96-week-old rats indicated that the Bcl-2 protein level was highest at E19 and decreased after birth. Bcl-x levels remained high from E19 to 96 weeks. Bax levels were high from E19 to 2 weeks and decreased from 4 weeks onward. Bak levels were highest at E19 and decreased abruptly after birth. Bad levels were high from E19 to 2 weeks and decreased abruptly at 4 weeks. The present results suggest that the expression of each Bcl-2 family protein is differentially regulated during development and aging and that the changes in the senescent brains are different from those observed in AD. |
| Databáze: | OpenAIRE |
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