Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice

Autor: Amanda Cano, C. Auladell, Marta Barenys, Jaume Folch, Miren Ettcheto, Patric Turowski, Maria Luisa García, Eliana B. Souto, Antonio Camins, Marta Espina, Elena Sánchez-López, Britta A. Kühne
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Ciências Biológicas [Ciências Naturais]
Medicine (miscellaneous)
Plga peg
Nanoparticle
Pharmacology
Catechin
3-nitropropionic acid
Polyethylene Glycols
Desenvolupament de medicaments
Mice
chemistry.chemical_compound
0302 clinical medicine
Polylactic Acid-Polyglycolic Acid Copolymer
neurodegenerative diseases
heterocyclic compounds
General Materials Science
Glycolic acid
0303 health sciences
Nanopartícules
Malalties neurodegeneratives
food and beverages
pigallocatechin-3-gallate
Neurodegenerative Diseases
Gallate
Nitro Compounds
3. Good health
3-nitropropionic acide
polymeric nanoparticles
epigallocatechin-3-gallate
Christian ministry
PLGA-PEG
Biomedical Engineering
Huntingtons disease
Bioengineering
Drug development
Development
complex mixtures
03 medical and health sciences
Regional development
Animals
030304 developmental biology
Ciências Naturais::Ciências Biológicas
Science & Technology
technology
industry
and agriculture
Polymeric nanoparticles
chemistry
Nanoparticles
sense organs
Propionates
030217 neurology & neurosurgery
Zdroj: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Dipòsit Digital de la UB
Universidad de Barcelona
Popis: Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-administered and behavioral motor assessments and striatal histology performed after 5 days. Results: EGCG/AA NPs were significantly more effective than free EGCG in reducing motor disturbances and depression-like behavior associated with 3-nitropropionic acid toxicity. EGCG/AA NPs treatment also mitigated neuroinflammation and prevented neuronal loss. Conclusion: NP encapsulation enhances therapeutic robustness of EGCG in this model of HD symptomatology. Together with our previous findings, this highlights the potential of EGCG/AA NPs in the symptomatic treatment of neurodegenerative diseases.
This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2017-84283-R), CB06/05/0024 (CIBERNED) and the European Regional Development Funds. A Camins, M Ettcheto, E Sanchez-Lopez and ML Garc ' ia belong to 2017SGR-1477. M Ettcheto, C Auladell and A Camins belong to 2017SGR-625.he The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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