Efficacy of ixazomib for the treatment of relapsed/refractory multiple myeloma: A protocol of systematic review and meta-analysis
| Autor: | Wan-Li Wang, Zhi Li, Shu-Li Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Boron Compounds
safety medicine.medical_specialty ixazomib efficacy MEDLINE Glycine PsycINFO CINAHL Cochrane Library Ixazomib 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Clinical Protocols relapsed/refractory multiple myeloma Study Protocol Systematic Review Medicine Humans Medical physics 030212 general & internal medicine Multiple myeloma Protocol (science) business.industry General Medicine medicine.disease Treatment Outcome chemistry 030220 oncology & carcinogenesis Meta-analysis Neoplasm Recurrence Local business Multiple Myeloma Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: Over the past years, ixazomib has been increasingly explored for the treatment of relapsed/refractory multiple myeloma (RRMM). However, its results are still contradictory. This study will explore the efficacy and safety of ixazomib for patients with RRMM. Methods: A systematic records search of Cochrane Library, PUBMED, EMBASE, CINAHL, ACMD, PsycINFO, WANGFANG, and China National Knowledge Infrastructure will be carried out from their origin to March 31, 2020 with no limitations of language and publication status. Trials will be selected by titles/abstracts, and full manuscripts by 2 independent authors. Data collection will be carried out from eligible trials based on the previous designed criteria. Study quality will be checked using Cochrane risk of bias, and statistical analysis will be administered by RevMan 5.3 software. Results: This study will summarize the current high-quality trials investigating the efficacy and safety of ixazomib for the treatment of patients with RRMM. Conclusion: The results of this study may provide convinced evidence on the evidence-based medicine level, and guidance for clinical practice and future studies. INPLASY Registration Number: INPLASY202040027. |
| Databáze: | OpenAIRE |
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