Fetal globin stimulation during a short-term trial of erythropoietin in HbS/beta-thalassemia patients
| Autor: | Bourantas Kl, K. Seferiadis, I. Georgiou |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Hemolytic anemia
Adult Erythrocyte Indices Male medicine.medical_specialty Time Factors Adolescent Recombinant Proteins/administration & dosage Anemia Sickle Cell hemic and lymphatic diseases Internal medicine Fetal hemoglobin Medicine Humans Globin Ferrous Compounds Erythrocyte Indices/drug effects Child Erythropoietin Anemia Sickle Cell/blood/*drug therapy Fetal Hemoglobin Globins/analysis/*drug effects Fetus business.industry Ferrous Compounds/administration & dosage beta-Thalassemia Beta thalassemia Hematology General Medicine Middle Aged medicine.disease Fetal Hemoglobin/analysis/drug effects Sickle cell anemia Recombinant Proteins Stimulation Chemical Globins Hemoglobinopathy Endocrinology beta-Thalassemia/blood/*drug therapy Erythropoietin/*administration & dosage Drug Evaluation Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Acta haematologica. 92(2) |
| ISSN: | 0001-5792 |
| Popis: | Six sickle cell/beta-thalassemia patients (3 males and 3 females) were treated with 500 U/kg body weight human recombinant erythropoietin (h-rEPO) along with 300 mg/day iron sulfate in two phases, for a period of 90 days. Fetal hemoglobin (HbF) was assayed every 2 weeks and the gamma-chain ratio at three successive intervals during the treatment. All patients showed a moderate to high increase in their HbF values (1.25- to 12-fold). The gamma-chain ratio, as determined by high performance liquid chromatography was found to be unaffected by the HbF increase. Two patients with the newborn gamma-chain ratio, responded faster to the h-rEPO treatment and achieved higher HbF values than the rest of the group. The h-rEPO treatment was very well tolerated and had a positive effect on the general clinical condition of all the patients. Acta Haematol |
| Databáze: | OpenAIRE |
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