SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation
| Autor: | Jia-lei Wang, Fan-zhen Lu, Yun Wu, Xiao-yong Shen, Li-ting Zhao |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Lung Neoplasms
Biophysics Down-Regulation Adenocarcinoma Biology Biochemistry SAM Domain and HD Domain-Containing Protein 1 Immune system Cell Line Tumor Gene expression medicine Humans RNA Messenger Promoter Regions Genetic Lung cancer Molecular Biology Cell Proliferation Monomeric GTP-Binding Proteins Lung Cell growth Gene Expression Profiling Cell Biology Methylation DNA Methylation respiratory system medicine.disease Molecular biology respiratory tract diseases Gene Expression Regulation Neoplastic medicine.anatomical_structure Gene Expression Regulation Cancer research SAMHD1 |
| Zdroj: | Biochemical and Biophysical Research Communications. 455:229-233 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2014.10.153 |
| Popis: | The function of dNTP hydrolase SAMHD1 as a viral restriction factor to inhibit the replication of several viruses in human immune cells was well established. However, its regulation and function in lung cancer have been elusive. Here, we report that SAMHD1 is down regulated both on protein and mRNA levels in lung adenocarcinoma compared to adjacent normal tissue. We also found that SAMHD1 promoter is highly methylated in lung adenocarcinoma, which may inhibit its gene expression. Furthermore, over expression of the SAMHD1 reduces dNTP level and inhibits the proliferation of lung tumor cells. These results reveal the regulation and function of SAMHD1 in lung cancer, which is important for the proliferation of lung tumor cells. |
| Databáze: | OpenAIRE |
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