Research progress on the treatment of advanced prostate cancer with Olaparib
| Autor: | Xue-Lei Chu, Cheng-Feng Yu, Peng Xue, Shijie Zhu, Lin-Lu Li, Kunmin Xiao, Yi-Xin Su |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Combination therapy medicine.medical_treatment Synthetic lethality Poly(ADP-ribose) Polymerase Inhibitors Piperazines Olaparib Androgen deprivation therapy chemistry.chemical_compound Prostate cancer Internal medicine medicine Humans Adverse effect Chemotherapy business.industry Androgen Antagonists medicine.disease Prostatic Neoplasms Castration-Resistant chemistry Cancer cell Phthalazines business |
| Zdroj: | Neoplasma. 68:1132-1138 |
| ISSN: | 1338-4317 |
| Popis: | Prostate cancer (PCa) is one of the most common malignancies in men worldwide, and metastatic castrate-resistant prostate cancer (mCRPC) has shown a poor prognosis. Although chemotherapy and androgen deprivation therapy (ADT) have improved clinical outcomes, the median survival (MS) of patients with mCRPC is still less than 2 years. With the development of poly adenosine diphosphate-ribose polymerase inhibitor (PARPi), the treatment strategy for patients with mCRPC has markedly evolved. Olaparib, a type of PARPi that can selectively induce synthetic lethality in cancer cells with homologous recombination (HR) deficiencies, was the first type of PARPi approved for treating patients with mCRPC harboring mutations in HR repair (HRR) genes. This review discusses and summarizes the latest progress on therapeutic mechanisms, monotherapy, combination therapy, and adverse events of Olaparib. |
| Databáze: | OpenAIRE |
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