Dolyemycins A and B, two novel cyclopeptides isolated from Streptomyces griseus subsp. griseus HYS31
| Autor: | Daojing Zhang, Xiao-dong Liu, Sha-Sha Xia, Yuanguang Li, Kang-bo Gu |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular 0301 basic medicine Protein Conformation Stereochemistry Antineoplastic Agents Peptides Cyclic 01 natural sciences 03 medical and health sciences Protein structure Drug Discovery Ic50 values Humans Amino Acid Sequence Peptide sequence Pharmacology chemistry.chemical_classification biology 010405 organic chemistry Human lung cancer Streptomyces griseus biology.organism_classification 0104 chemical sciences Amino acid 030104 developmental biology chemistry A549 Cells |
| Zdroj: | The Journal of Antibiotics. 71:838-845 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/s41429-018-0071-x |
| Popis: | Two novel cyclopeptides with special skeleton, namely, dolyemycins A (1) and B (2) were isolated from Streptomyces griseus subsp. griseus HYS31 by bio-guided isolation. Their structures were elucidated by detailed analysis of spectroscopic data. These two compounds were cyclopeptides containing eleven amino acids including five unusual amino acids (hydroxyglycine, 3-hydroxyleucine, 3-phenylserine, β-hydroxy-O-methyltyrosine, 2,3-diaminobutyric acid) in both of them and an extra nonprotein amino acids (3-methylaspartic acid) in Dolyemycin B only. Dolyemycins A and B performed antiproliferative activity against human lung cancer A549 cells with IC50 values of 1.0 and 1.2 µM, respectively. |
| Databáze: | OpenAIRE |
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