Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea
Autor: | Rhobert W. Evans, Dorothy Leann Long, Chol Shin, Akira Sekikawa, Abhishek Vishnu, Yasuyuki Nakamura, Vasudha Ahuja, Jina Choo, Akira Fujiyoshi, Emma Barinas-Mitchell, Aya Kadota, Katsuyuki Miura, Takashi Hisamatsu, Hirotsugu Ueshima, Kamal Masaki |
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Rok vydání: | 2018 |
Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Cross-sectional study Cvd risk Population Ethnic group 030204 cardiovascular system & hematology Carotid Intima-Media Thickness White People 03 medical and health sciences symbols.namesake 0302 clinical medicine Asian People Japan Risk Factors Republic of Korea Epidemiology Humans Medicine cardiovascular diseases 030212 general & internal medicine Poisson regression education education.field_of_study business.industry Middle Aged Plaque Atherosclerotic United States Coronary heart disease Cross-Sectional Studies symbols Cardiology and Cardiovascular Medicine business Chd risk Demography |
Zdroj: | International Journal of Cardiology. 266:245-249 |
ISSN: | 0167-5273 |
Popis: | Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk.We conducted a population-based study among apparently healthy middle-aged men aged 40-49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined.Whites (22.8%) had more than four-fold higher prevalence (p 0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors - incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population.Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors. |
Databáze: | OpenAIRE |
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