Effects of Saussurea costus on apoptosis imbalance and inflammation in benign prostatic hyperplasia
| Autor: | Jinho An, Jiyeon Kim, Hyunseok Kong, Seung-Hyun Sung, Do-Hyun Choi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Saussurea Anti-Inflammatory Agents Prostatic Hyperplasia Apoptosis Pharmacology 03 medical and health sciences 0302 clinical medicine Prostate Drug Discovery medicine Animals Rats Wistar Testosterone 030304 developmental biology Inflammation 0303 health sciences biology Dose-Response Relationship Drug business.industry Plant Extracts Hyperplasia Apoptotic body biology.organism_classification medicine.disease Saussurea costus Rats Disease Models Animal medicine.anatomical_structure 030220 oncology & carcinogenesis Dihydrotestosterone Disease Progression Benign prostatic hyperplasia (BPH) business Costus medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 279 |
| ISSN: | 1872-7573 |
| Popis: | Ethnopharmacological relevance Saussurea costus (synonym: Aucklandia lappa Decne) is a medicinal plant distributed in Yunnan, Guangxi, and Sichuan in China. In traditional Korean medicine, the plant parts (especially the root—“radix aucklandiae”) is widely used to treat vomiting, diarrhea, and inflammation. However, little has been reported on its effect on benign prostatic hyperplasia (BPH), which is common in middle-aged men. Aim of the study BPH is caused by apoptosis imbalance and inflammation due to aging of the prostate. Therefore, the aim of this was to prove the efficacy of S. costus by analyzing its effect on the biological mechanisms leading to BPH progression. Materials and methods Wistar rats were injected subcutaneously with a single dose of testosterone (125 mg/kg) to induce BPH, and were later administered with S. costus (20, 40 mg/kg). After 12 weeks, histological changes in the prostate and hormone regulation factors were assessed in all animals. Furthermore, apoptotic protein and apoptotic body values were analyzed to confirm the improvement of apoptosis imbalance, and inflammatory cytokines were analyzed to confirm the anti-inflammatory efficacy of S. costus. Results In the serum and tissue of S. costus-treated BPH rats, a significant reduction in prostate weight, prostate index, and hormone regulation factors was observed. S. costus also increased the levels of apoptosis marker proteins and reduced the levels of inflammatory cytokines. It also decreased the expression of B-cell lymphoma 2 (BCL-2) and increased the expression of BCL-2 associated X protein (BAX) in the prostate. Histological changes such as epithelial thickness significantly increased in BPH induced group but significantly decreased in the S. costus-treated groups (p Conclusions S. costus may prevent and treat BPH occurrence by modulating inflammation and apoptosis imbalance. |
| Databáze: | OpenAIRE |
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