Cannabinoid exposure and altered DNA methylation in rat and human sperm

Autor:	Marty Cauley, Douglas J. Raburn, Marie-Helene Boudreau, Susan K. Murphy, F. Joseph McClernon, Edward D. Levin, Brandon J. Hall, David L. Corcoran, Carole Grenier, Rose Schrott, Kelly S. Acharya, Nilda Itchon-Ramos, Zhiqing Huang, Scott H. Kollins, John T. Mitchell, Thomas M Price, Zachary Visco, Joseph E. Lucas
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Male Cancer Research medicine.medical_specialty Marijuana Abuse Adolescent medicine.medical_treatment epigenetic reprogramming sperm Rats Sprague-Dawley 03 medical and health sciences tetrahydrocannabinol Internal medicine mental disorders medicine Animals Humans rat Dronabinol human Tetrahydrocannabinol Molecular Biology Cannabis Cannabinoid Receptor Agonists DNA methylation biology organic chemicals biology.organism_classification Sperm Spermatozoa Rats 030104 developmental biology Endocrinology CpG Islands Cannabinoid Reprogramming Reproductive effects medicine.drug Research Paper
Zdroj:	Epigenetics
ISSN:	1559-2308
Popis:	Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Pathway analyses indicated Hippo Signaling and Pathways in Cancer as enriched with altered genes (Bonferroni p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47387f0659eedaad43f263394627c8a https://pubmed.ncbi.nlm.nih.gov/30521419 Zobrazit plný text záznamu