| Autor: |
Christopher Zappala, Nicole S L Goh, Ian Glaspole, E. Haydn Walters, Britt Clynick, Gregory J Keir, Peter Hopkins, Marissa Ryan, Dino Tan, Paul N. Reynolds, Wendy A Cooper, Svetlana Baltic, Samantha Ellis, Christopher Grainge, Helen E. Jo, Annabelle Mahar, Yuben Moodley, Sally Chapman, Tamera J. Corte |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
The European respiratory journal. 54(5) |
| ISSN: |
1399-3003 |
| Popis: |
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by an overall poor prognosis. The rate of disease decline and progression to death can vary, with some patients remaining stable over longer periods of time and others displaying rapid progression [1, 2]. The highly heterogeneous nature of this disease makes it difficult to elucidate the pathways involved in the initiation and progression of IPF and what determines the clinical trajectory of these patients. Advances in high-throughput gene expression analyses have led to improvements in our understanding of disease biology with insights into prognostic and predictive gene signatures [3]. This study sought to characterise differences in gene expression profiles found in the circulation between “stable” and “progressive” IPF patients, to help identify relevant biomarkers that may provide insights into the pathogenesis of progressive IPF. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Miss Clynick has nothing to disclose. Conflict of interest: Dr. Jo has nothing to disclose. Conflict of interest: Dr. Corte has nothing to disclose. Conflict of interest: Dr. Glaspole has nothing to disclose. Conflict of interest: Dr. Grainge has nothing to disclose. Conflict of interest: Dr. Hopkins has nothing to disclose. Conflict of interest: Dr. Reynolds has nothing to disclose. Conflict of interest: Dr. Chapman has nothing to disclose. Conflict of interest: Dr. Walters has nothing to disclose. Conflict of interest: Dr. Zappala has nothing to disclose. Conflict of interest: Dr. Keir has nothing to disclose. Conflict of interest: Dr. Cooper has nothing to disclose. Conflict of interest: Dr. Mahar has nothing to disclose. Conflict of interest: Dr. Ellis has nothing to disclose. Conflict of interest: Dr. Goh has nothing to disclose. Conflict of interest: Dr. Baltic has nothing to disclose. Conflict of interest: Miss Ryan has nothing to disclose. Conflict of interest: Dr. Tan has nothing to disclose. Conflict of interest: Dr. Moodley has nothing to disclose. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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