Analysing the effect of multiple sclerosis on vitamin D related biochemical markers of bone remodelling
| Autor: | Barbara Murray, Ricardo Segurado, Mark Kilbane, Roisin Lonergan, Malachi J. McKenna, Niall Tubridy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Vitamin
Adult Male medicine.medical_specialty Multiple Sclerosis Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Parathyroid hormone Renal function Biochemistry vitamin D deficiency Collagen Type I Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology N-terminal telopeptide Internal medicine Vitamin D and neurology medicine Humans 030212 general & internal medicine Vitamin D education Molecular Biology education.field_of_study Cell Biology Middle Aged medicine.disease Vitamin D Deficiency Peptide Fragments chemistry Parathyroid Hormone Molecular Medicine Female Bone Remodeling Seasons Peptides Ireland 030217 neurology & neurosurgery Biomarkers Procollagen |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 177 |
| ISSN: | 1879-1220 |
| Popis: | The Irish population is at risk of vitamin D deficiency during the winter months, but the secular trend over the past 40 years is for marked improvement. Multiple sclerosis (MS) is common in Ireland with a latitudinal pattern favouring highest incidence in northern regions; MS is linked strongly with vitamin D status as a causal factor. We sought firstly to study the relationship between vitamin D status and vitamin D-related bone biochemistry, and secondly to evaluate if MS had an independent effect on vitamin D related markers of bone remodelling. Using a case-control design of 165 pairs (MS patient and matched control) residing in three different geographic regions during winter months, we measured serum 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), C-terminal telopeptide of type I collagen (CTX) and total procollagen type I amino-terminal propeptide (PINP). Given the paired case-control design, associations were explored using mixed-effects linear regression analysis with the patient-control pair as a random effect and after log transformation of 25OHD. A two-way interaction effect was tested for vitamin D status (25OHD |
| Databáze: | OpenAIRE |
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